Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABAA blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
Molecular Weight:
509.29
Purity:
99.93
CAS Number:
[40709-69-1]
Formula:
C21H20INO6
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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