GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4-NKX2-5 transcriptional synergy with an IC50 of 3 µM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].
Molecular Weight:
349.43
Purity:
99.24
CAS Number:
[544681-96-1]
Formula:
C21H23N3O2
Target:
IKZF Family
Application Notes:
MCE Product type: Reference compound
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