Takinib (Standard), CAS [[1111556-37-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-103490R
Supplier Catalog Number:
HY-103490R
Alternative Catalog Number:
MCE-HY-103490R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
EDHS-206 (Standard)
Takinib (Standard) is the analytical standard of Takinib. This product is intended for research and analytical applications. Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFalpha stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 µM)[1][2][3].
Molecular Weight:
322.36
CAS Number:
[1111556-37-6]
Formula:
C18H18N4O2
Target:
Apoptosis,MAP3K,Reference Standards
Application Notes:
MCE Product type: Reference Standards
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