AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPgammaS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2].
Molecular Weight:
465.46
Purity:
99.83
CAS Number:
[97075-46-2]
Formula:
C28H30Cl2N2
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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