LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 µM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 µM. LY456236 blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research[1][2][3].
Molecular Weight:
317.78
Purity:
99.57
CAS Number:
[338736-46-2]
Formula:
C16H16ClN3O2
Target:
Apoptosis,EGFR,mGluR,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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