Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRbeta (platelet-derived growth factor receptor beta). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction[1].
Molecular Weight:
480.54
Purity:
99.51
CAS Number:
[623142-96-1]
Formula:
C24H24N4O5S
Target:
c-Fms,c-Kit,PDGFR,VEGFR
Application Notes:
MCE Product type: Reference compound1
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