Pevonedistat hydrochloride (Standard), CAS [[1160295-21-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-10484R
Supplier Catalog Number:
HY-10484R
Alternative Catalog Number:
MCE-HY-10484R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Pevonedistat hydrochloride (Standard) is the analytical standard of Pevonedistat hydrochloride (HY-10484). This product is intended for research and analytical applications. Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice[1].
