Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha, and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC50=1.3 µM). Tenidap is applicable to research related to rheumatoid arthritis[1][2][3][4].
Molecular Weight:
320.75
Purity:
99.32
CAS Number:
[120210-48-2]
Formula:
C14H9ClN2O3S
Target:
COX,Lipoxygenase,MMP,Potassium Channel
Application Notes:
MCE Product type: Reference compound
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