Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3].
Molecular Weight:
428.53
CAS Number:
[109826-26-8]
Formula:
C26H28N4O2
Target:
Calmodulin
Application Notes:
MCE Product type: Reference compound
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