RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-delta (PI3Kdelta). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC50=12 nM), showing twice the selectivity for PI3Kdelta relative to PI3Kgamma. RV-1729 is also 16 times more selective to PI3Kalpha. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kdelta. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD)[1].
Molecular Weight:
735.23
CAS Number:
[1293915-42-0]
Formula:
C39H39ClN8O5
Target:
PI3K
Application Notes:
MCE Product type: Reference compound
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