F-14512 is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 can be used to study breast cancer[1].
Molecular Weight:
641.75
Purity:
97.48
CAS Number:
[866874-63-7]
Formula:
C33H47N5O8
Target:
DNA/RNA Synthesis,Topoisomerase
Application Notes:
Reference compound
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