DTS-201 (CPI-0004) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer[1].
Molecular Weight:
1012.06
CAS Number:
[274912-87-7]
Formula:
C49H65N5O18
Target:
Aminopeptidase,Peptide-Drug Conjugates (PDCs)
Application Notes:
MCE Product type: Reference compound
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