THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants[1][2].
Molecular Weight:
589.17
Purity:
98.48
CAS Number:
[312637-48-2]
Formula:
C33H41ClN6O2
Target:
Melanocortin Receptor
Application Notes:
MCE Product type: Reference compound
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