Adrenocorticotropic hormone (ACTH, Adrenocorticotrophic hormone) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone regulates cortisol and androgen production. Adrenocorticotropic hormone can promote the development of spermatogenesis. Adrenocorticotropic hormone can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome[1][2][3][4].
Molecular Weight:
4541.14
Purity:
99.17
CAS Number:
[9002-60-2]
Formula:
C207H308N56O58S
Target:
Androgen Receptor,Interleukin Related,Mitochondrial Metabolism,Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
MCE Product type: Reference compound
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