AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells[1].
Molecular Weight:
475.52
CAS Number:
[845895-51-4]
Formula:
C26H30N5O2P
Target:
Apoptosis,c-Kit
Application Notes:
MCE Product type: Reference compound
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