Mosapramine (Clospipramine) is an orally effective antipsychotic agent and one of the metabolites of Clocapramine (HY-B2073) after oral absorption. Mosapramine exerts its effects by specifically binding to striatal dopamine D2 receptors and frontal lobe 5-HT2 receptors, with a D2/5-HT2 receptor occupancy ratio of 7.4. Mosapramine induces typical neuropharmacological responses in rat brain regions, including extrapyramidal symptoms, hyperprolactinemia, increased salivation, constipation, and upregulated Fos protein expression. Mosapramine also features a reduced incidence of weight loss. Mosapramine is applicable to research related to schizophrenia[1][2][3].
Molecular Weight:
479.06
Purity:
98.58
CAS Number:
[89419-40-9]
Formula:
C28H35ClN4O
Target:
5-HT Receptor,Dopamine Receptor,Drug Derivative
Application Notes:
MCE Product type: Reference compound1
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