Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkins and non-Hodgkins lymphoma treatment[1][2][3][4].
Molecular Weight:
184.20
Purity:
99.33
CAS Number:
[459-86-9]
Formula:
C5H12N8
Target:
Apoptosis,HIV
Application Notes:
MCE Product type: Reference compound1
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