Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1, ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 µM). Ponalrestat inhibits the conversion of glucose to sorbitol[1][2][3].
Molecular Weight:
391.19
Purity:
99.51
CAS Number:
[72702-95-5]
Formula:
C17H12BrFN2O3
Target:
Aldose Reductase
Application Notes:
MCE Product type: Reference compound1
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