Asoxime dichloride (HI-6) is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and alpha7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system[1][2].
Molecular Weight:
359.21
Purity:
98.47
CAS Number:
[34433-31-3]
Formula:
C14H16Cl2N4O3
Target:
Cholinesterase (ChE),nAChR
Application Notes:
MCE Product type: Reference compound
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