Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
Molecular Weight:
491.52
Purity:
99.67
CAS Number:
[403604-85-3]
Formula:
C24H21N5O5S
Target:
Endothelin Receptor
Application Notes:
MCE Product type: Reference compound1
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