AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor, AR-A 2 can be used in the research of depression and anxiety.
Molecular Weight:
448.60
CAS Number:
[220051-79-6]
Formula:
C27H36N4O2
Target:
5-HT Receptor
Application Notes:
MCE Product type: Reference compound
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