GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimers disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions)[1][2].
Molecular Weight:
333.40
Purity:
99.78
CAS Number:
[932373-87-0]
Formula:
C18H24FN3O2
Target:
mAChR
Application Notes:
MCE Product type: Reference compound
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