AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-alpha, IFN-gamma, IL-10 and IL-17A.
Molecular Weight:
339.40
Purity:
99.73
CAS Number:
[1370544-73-2]
Formula:
C21H22FNO2
Target:
IFNAR,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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