AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol delta7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol delta7-delta8 isomerase, which causes the accumulation of cholest-8-en-3beta-ol[1][2][3].
Molecular Weight:
464.30
Purity:
99.67
CAS Number:
[366-93-8]
Formula:
C22H30Cl4N2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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