Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53[1][2].
Molecular Weight:
502.55
Purity:
99.89
CAS Number:
[3148-09-2]
Formula:
C27H34O9
Target:
Apoptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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