RO 4938581 is a potent and selective GABAA alpha5 inverse agonist, with a Ki of 4.6 nM for GABAA alpha5beta3gamma2a, and shows a lower affinity at alpha1beta3gamma2a, alpha2beta3gamma2a, alpha3beta3gamma2a (Ki, 174, 185, 80 nM, respectively), RO 4938581 is used in the research of cognitive dysfunction.
Molecular Weight:
352.14
Purity:
99.78
CAS Number:
[883093-10-5]
Formula:
C13H8BrF2N5
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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