VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
Molecular Weight:
330.78
Purity:
98.94
CAS Number:
[1309976-62-2]
Formula:
C18H16ClFN2O
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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