YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freunds adjuvant (HY-153808)-induced arthritic pain models[1].
Molecular Weight:
360.52
CAS Number:
[446257-23-4]
Formula:
C19H28N4OS
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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