Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[1][2].
Molecular Weight:
408.58
Purity:
99.25
CAS Number:
[1128165-88-7]
Formula:
C25H36N4O
Target:
Apoptosis,Dynamin
Application Notes:
MCE Product type: Reference compound
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