TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin alpha2beta1 inhibitor, and it also inhibits alpha1beta1 and alpha11beta1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, [1][2].
Molecular Weight:
520.62
Purity:
99.94
CAS Number:
[916734-43-5]
Formula:
C23H28N4O6S2
Target:
Integrin
Application Notes:
MCE Product type: Reference compound
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