Arundic Acid is an orally effective astrocyte function modulator and neuroprotective agent. Arundic Acid increases the expression and function of the astrocytic glutamate transporter EAAT1 by activating the ERK, Akt and NF-kappaB pathways. Arundic Acid attenuates retinal ganglion cell death in a normal-tension glaucoma model. Arundic Acid exerts neuroprotective effects in a mouse model of Parkinsons disease. Arundic Acid is a S100beta protein synthesis inhibitor that prevents neurological deficits and brain tissue damage after intracerebral hemorrhage in rats. Arundic Acid downregulates neuroinflammation and astrocytic dysfunction after status epilepticus in immature rats. Arundic Acid is applicable to research related to Parkinsons disease, cerebral ischemia, glaucoma, intracerebral hemorrhage and epilepsy[1][2][3][4][5].
Molecular Weight:
186.29
Purity:
98
CAS Number:
[185517-21-9]
Formula:
C11H22O2
Target:
Akt,EAAT,ERK,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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