Bezisterim (HE 3286, NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, beta-AET. Bezisterim is an orally active partial NF-kappaB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis[1][2][3]. Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
330.46
Purity:
95
CAS Number:
[1001100-69-1]
Formula:
C21H30O3
Target:
NF-kappaB
Application Notes:
Reference compound
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