Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].
Molecular Weight:
573.56
Purity:
99.27
CAS Number:
[113857-87-7]
Formula:
C27H27N9O6
Target:
Antifolate,Dihydrofolate reductase (DHFR)
Application Notes:
MCE Product type: Reference compound
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