Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].
Molecular Weight:
590.59
CAS Number:
[648420-92-2]
Formula:
C27H30N10O6
Target:
Antifolate,Dihydrofolate reductase (DHFR)
Application Notes:
MCE Product type: Reference compound
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