3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 µM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
Molecular Weight:
586.64
Purity:
98.18
CAS Number:
[179237-49-1]
Formula:
C35H30N4O5
Target:
FLT3
Application Notes:
MCE Product type: Reference compound
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