MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1].
Molecular Weight:
415.50
Purity:
99.94
CAS Number:
[1454920-20-7]
Formula:
C17H20F3N5S2
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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