AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 µM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1].
Molecular Weight:
543.93
CAS Number:
[1642112-32-0]
Formula:
C25H16ClF2N3O5S
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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