JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17µM[1]. JW67 affects the multiprotein complex consisting of beta-catenin/GSK-3beta/AXIN/APC/CK1 that rapidly reduces active beta-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
Molecular Weight:
394.38
Purity:
98.15
CAS Number:
[442644-28-2]
Formula:
C21H18N2O6
Target:
Wnt
Application Notes:
MCE Product type: Reference compound1
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