ER 50891 is a RARalpha antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis[1].
Molecular Weight:
432.51
Purity:
99.86
CAS Number:
[187400-85-7]
Formula:
C29H24N2O2
Target:
RAR/RXR
Application Notes:
MCE Product type: Reference compound
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