Rp-8-Br-PET-cGMPS (sodium), CAS [[185246-32-6]] Preis auf Anfrage

Product Overview

• Article Name: Rp-8-Br-PET-cGMPS (sodium), CAS [[185246-32-6]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-108548
• Supplier Catalog Number: HY-108548
• Alternative Catalog Number: MCE-HY-108548-5MG,MCE-HY-108548-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: Rp-8-Bromo-PET-cGMPS

Product Description

Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 µM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 µM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 µM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

Product Properties

• Molecular Weight: 562.27
• Purity: 99.4
• CAS Number: [185246-32-6]
• Formula: C18H14BrN5NaO6PS
• Target: PKG

Application Notes

• Application Notes: MCE Product type: Reference compound1