RWJ-56110 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 µM) and thrombin (IC50=0.34 µM), quite selective relative to U46619 (HY-108566). RWJ-56110 inhibits angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 induces cell apoptosis[1][2].
Molecular Weight:
790.73
CAS Number:
[252889-88-6]
Formula:
C41H43Cl2F2N7O3
Target:
Apoptosis,Protease Activated Receptor (PAR)
Application Notes:
MCE Product type: Reference compound
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