DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCepsilon. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].
Molecular Weight:
308.50
Purity:
98.00
CAS Number:
[28399-31-7]
Formula:
C20H36O2
Target:
Apoptosis,CaMK,Phosphatase,PKC
Application Notes:
MCE Product type: Reference compound
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