WAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC50 of 0.02 µM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/beta-catenin signaling pathway (EC50 = 0.03 µM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis[1].
Molecular Weight:
644.73
Purity:
99.91
CAS Number:
[915763-27-8]
Formula:
C28H35F3N4O6S2
Target:
sFRP-1,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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