Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, alpha-globin, beta-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3].
Molecular Weight:
455.96
Purity:
99.96
CAS Number:
[105219-56-5]
Formula:
C22H22ClN5O2S
Target:
Platelet-activating Factor Receptor (PAFR)
Application Notes:
MCE Product type: Reference compound
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