alpha,beta-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. alpha,beta-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC), this effect can be blocked by the P2X antagonist PPADS (HY-108960). alpha,beta-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects, this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). alpha,beta-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system[1][2][3].
Molecular Weight:
571.15
Purity:
99
CAS Number:
[1343364-54-4]
Formula:
C11H15N5Na3O12P3
Target:
P2X Receptor
Application Notes:
MCE Product type: Reference compound
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