NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively[1]. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA)[2].
Molecular Weight:
1437.10
Purity:
99.13
CAS Number:
[104869-26-3]
Formula:
C49H28F2N6Na6O23S6
Target:
P2Y Receptor
Application Notes:
MCE Product type: Reference compound
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