PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma[1][2].
Molecular Weight:
523.63
Purity:
99.48
CAS Number:
[1407966-77-1]
Formula:
C30H33N7O2
Target:
Btk,CXCR,Itk,LAG-3,PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
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