GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a Kd value of 2.1 µM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage[1][2].
Molecular Weight:
300.35
Purity:
99.91
CAS Number:
[2143475-98-1]
Formula:
C20H16N2O
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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