Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria[1].
Molecular Weight:
459.48
Purity:
99.57
CAS Number:
[288591-93-5]
Formula:
C16H25N7O7S
Target:
Aminoacyl-tRNA Synthetase,Bacterial
Application Notes:
Reference compound
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