JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 µM, 27 µM and 5.18 µM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity[1].
Molecular Weight:
323.35
Purity:
99.75
CAS Number:
[942655-44-9]
Formula:
C18H17N3O3
Target:
FGFR,VEGFR
Application Notes:
Reference compound
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